Hypoxia induced changes in the brain of hypoxic tolerant cuttlefish Sepia officinalis
نویسندگان
چکیده
C. Bock, S. Schmidt, F. Melzner, H-O. Poertner Ecopysiology and Ecotoxicology, Alfred-Wegener-Institute, Bremerhaven, Bremen, Germany Introduction Marine invertebrates are frequently used as model organisms in neurological research. Especially experiments on isolated neurons of snails or the giant axon of cuttlefish contributed to a basic and fundamental understanding in neuronal signal transduction and reception (e.g. Kupfermann & Kandel 1969). More recently, a limited number of NMR studies on isolated neurons of marine invertebrates were reported in the literature (Schoeniger et al. 1994, Grant et al. 2000, Grant et al 2001). Since MR imaging and spectroscopy become more and more important to study overall brain function and connectivity, the aim of this study was to develop a setup for MR studies of brain function in the cuttlefish Sepia officinalis in vivo under different physiological conditions. Cephalopods, although invertebrates, have specialized skills (e.g. independent coordination of different arms) and are believed to display neural abilities and complexity similar to those of small rodents. These characters are associated with an energy consuming lifestyle. Nonetheless, the cuttlefish Sepia officinalis is a hypoxia tolerant species and may thus be an ideal model species for the study of hypoxia tolerant brain functions.
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Hypoxic Induced Decrease in Oxygen Consumption in Cuttlefish (Sepia officinalis) Is Associated with Minor Increases in Mantle Octopine but No Changes in Markers of Protein Turnover
The common cuttlefish (Sepia officinalis), a dominant species in the north-east Atlantic ocean and Mediterranean Sea, is potentially subject to hypoxic conditions due to eutrophication of coastal waters and intensive aquaculture. Here we initiate studies on the biochemical response to an anticipated level of hypoxia. Cuttlefish challenged for 1 h at an oxygen level of 50% dissolved oxygen satur...
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